0000033543 00000 n 0000003317 00000 n 3.1. 9 Reason: The coating solution penetrates the surface of the tablet, often at the crown where the surface is more porous, causing localized disintegration of the core and disruption of the coating. Heavy ink coverage. 0000049044 00000 n 0000046603 00000 n Formulating robust tablets is critical to minimizing defects that arise during film-coating application. 0000015161 00000 n 0000015589 00000 n Tablet breaking force (or tensile strength) must be maximized, while minimizing tablet friability. 0000046847 00000 n The raw materials may be of poor quality or do not meet specification, causing excessive fines that lead to a host of defects. 2. • Inappropriate tablet shape - Select new tablet shape that minimizes chances of flat surfaces coming into contact during application of coating liquid (e.g. Once the coating has dried they break apart later under the influence of attrition. Tablet Coating Defects Presented by: Bhushan Sirsikar (NIPERA1719PE15) 2. Therefore, it is not surprising that those coatings can suffer from premature failure and/or exhibit defects that may or may not result in failure. Information about tablet coating and its defects 0000007893 00000 n Our Desktop Tablet Press range is incredibly popular among small businesses and entrepreneurs because of the low costs and ability to produce up to 5,000 tablets an hour. Slow drying can be caused by the following criteria: Film weight. Coating tablets with a thin polymer film can be an effective way to give your products a professional edge. As a result, the film coated tablets from all 24 batches demonstrated satisfactory physical appearance with few undesirable tablet coating defects such as tablet surface erosion or poor inter-tablet color uniformity. We classified the source of the defects into tableting or coating and also determined the reasons for occurrence of each defect type. 0000004260 00000 n Sr.No. T here are many ways to coat tablets. High intensity specular illumination will be used as necessary to assist in visual defect evaluation for coating. 115 0 obj <>stream Sr.No. 9 Reason: The coating solution penetrates the surface of the tablet, often at the crown where the surface is more porous, causing localized disintegration of the core and disruption of the coating. RemedyUse mild drying condition. �����M���0��ґ��&.�0>��Di܍@ ��. These markings include company name or symbol, product code, product name etc. Desktop Tablet Presses. We must know the root cause to avoid the problem. As the partially dried coating is extremely tacky, once the two tablets make contact they adhere to one another. As the partially dried coating is extremely tacky, once the two tablets make contact they adhere to one another. Defects in tablet are related to imperfections in any one or more of the following factors: MachineFormulationTableting Process 3. The inspection criteria used for coating, is based on MIL-F-48616. avoid capsule-shaped tablets with straight edges or thick side walls) • Reason: capping is because of air-entrapment during compression and subsequent expansion of the tablet on the ejection of a tablet … endstream endobj startxref A. High quality tablets can be quickly and easily produced using a tablet coating machine and the correct excipients.Unfortunately several defects can arise with coatings. They must be able to be applied in diverse environmental conditions and then be expected to protect the substrate from the 0 0000045333 00000 n Appearance Defects: 1. • Inappropriate tablet shape - Select new tablet shape that minimizes chances of flat surfaces coming into contact during application of coating liquid (e.g. The following is a list of the 10 least wanted coating defects, and their causes. DEFECTS IN FILM COATED TABLETS. DEFECTS IN FILM COATED TABLETS. Sugar coating was one of the earliest methods, and the process is still widely used in the confectionery industry. Black spots problem is observed in some organisations sometimes it has led to destruction of whole batch also. Tablets coating defects. It can be a stealthy defect, undetected until hardnesss and friability testing or until entering the pre-heat cycle of the coating process. This review covers a brief overview of tablet film coating technology and modeling approaches, with a focus on recent advancements in pharmaceutical applications. Black spots could come from machine due to … 0000016278 00000 n 2. We classified the source of the defects into tableting or coating and also determined the reasons for occurrence of each defect type. 0000082179 00000 n Capping:- ‘Capping’ is the term used, when the upper or lower segment of the tablet separates horizontally, either partially or completely from the main body of a tablet and comes off as a cap, during ejection from the tablet press, or during subsequent handling. At some stages of a typical pharmaceutical tablet manufacturing chain, tablets endure impacts on multiple occasions (such as tablet collection following compression, and loading/unloading of tablet coating pans), which can lead to defects such as chipping and breakage. 0000039079 00000 n A. 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